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Nitric oxide and oxidative stress in cardiovascular aging
Shubha V Y Raju1, Lili A Barouch, Joshua M Hare
1Cardiology Division, Department of Medicine, The Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Science of Aging Knowledge Environment : SAGE KE
|May 27, 2005
Summary
The free radical theory of aging is challenged by new findings. Reactive oxygen species (ROS) disrupt protein S-nitrosylation, affecting cell signaling and aging, suggesting a reevaluation of oxidative stress is needed.
Area of Science:
- Biochemistry
- Molecular Biology
- Gerontology
Background:
- The free radical theory of aging links cellular damage to reactive oxygen species (ROS).
- This theory is debated, with emerging evidence on reactive nitrogen species (RNS) interactions.
- Protein S-nitrosylation is a key posttranslational modification affected by ROS.
Purpose of the Study:
- To discuss the impact of ROS on protein S-nitrosylation within the cardiovascular system.
- To propose a reevaluation of aging and oxidative stress concepts.
- To highlight the importance of the balance between oxidative and nitrosative stress.
Main Methods:
- Literature review and theoretical discussion.
- Analysis of molecular interactions between ROS, RNS, and protein S-nitrosylation.
- Contextualization within cardiovascular system aging.
Main Results:
- Increased ROS can disrupt protein S-nitrosylation, a critical signaling pathway.
- ROS-induced disruption of S-nitrosylation contributes to cellular pathology and aging.
- The balance between oxidative and nitrosative stress is crucial for cellular function.
Conclusions:
- The traditional free radical theory of aging requires revision.
- Oxidative and nitrosative stress dynamics play a significant role in aging.
- Understanding these balances is key to reevaluating aging processes, particularly in the cardiovascular system.