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Bone tissue response to a methacrylate-based endodontic sealer: a histological and histometric study
Osvaldo Zmener1, Gladys Banegas, Cornelis H Pameijer
1Department of Adult Dental Care, Section of Endodontics, Faculty of Odontology, University of Buenos Aires, República Argentina. zmener@infovia.com.ar
Journal of Endodontics
|May 27, 2005
Summary
This study assessed bone reaction to a methacrylate-based endodontic sealer in rats. Initially, the sealer showed lower bone formation and higher inflammation, but these effects resolved by 60 days.
Area of Science:
- Biomaterials Science
- Dental Research
- Tissue Engineering
Background:
- Biocompatibility of endodontic sealers is crucial for successful root canal therapy.
- Evaluating the host response to novel endodontic materials is essential for clinical application.
Purpose of the Study:
- To assess the bone tissue reaction to a methacrylate-based endodontic sealer.
- To compare the biocompatibility of the sealer against a control material in vivo.
Main Methods:
- Histological and histometric analysis of bone tissue reaction.
- Implantation of methacrylate-based sealer and silicone rods (controls) into rat tibias.
- Evaluation at 10 and 60 days post-implantation.
Main Results:
- At 10 days, significantly less reactionary bone and higher inflammatory cell counts were observed around the sealer compared to controls (p < 0.05).
- By 60 days, no significant differences in reactionary bone were found between the sealer and control groups (p > 0.05).
- The initial inflammatory response to the sealer resolved over time, with no significant cellular differences at 60 days.
Conclusions:
- Methacrylate-based endodontic sealers elicit an initial inflammatory response and reduced bone formation.
- The observed inflammatory reaction and bone response to the sealer are transient and resolve by 60 days.
- The endodontic sealer demonstrates acceptable biocompatibility in the long term, indicating potential for clinical use.