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Treatment Outcomes Following Root Perforation Repair in Permanent Teeth: A Systematic Review and Meta-Analysis
Yee Ang1, Lay Ann Teh2, Jonathan Jun Xian Yuen3
1Department of Restorative Dentistry, Faculty of Dentistry, MAHSA University, 42610, Jenjarom, Selangor, Malaysia.
Journal of Endodontics
|August 8, 2026
Summary
Non-surgical root perforation repair in permanent teeth shows a high success rate of 89.7%. Smaller perforations (≤3 mm) and maxillary teeth have better outcomes, though evidence is limited.
Area of Science:
- Endodontics
- Dental Traumatology
- Regenerative Dentistry
Background:
- Root perforations compromise tooth prognosis.
- Effective repair is crucial for preserving permanent teeth.
- Identifying prognostic factors aids treatment planning.
Purpose of the Study:
- To systematically review and meta-analyze root perforation repair outcomes in permanent teeth.
- To identify prognostic factors influencing treatment success.
Main Methods:
- Systematic review and meta-analysis of observational studies (2000-2026).
- Searched multiple databases (PubMed, Embase, Scopus, etc.).
- Assessed risk of bias and certainty of evidence (Joanna Briggs Institute, GRADE).
Main Results:
- Pooled favorable outcome rate of 89.7% for non-surgical repair.
- Smaller perforations (≤3 mm) and maxillary teeth showed significantly better outcomes.
- Tooth type, location, gender, and preoperative factors were not significantly associated with outcomes.
Conclusions:
- Non-surgical root perforation repair demonstrates favorable outcomes, especially for smaller defects and in maxillary teeth.
- Findings suggest a positive prognosis for treated root perforations.
- Caution is advised due to clinical heterogeneity and low-certainty evidence.