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Updated: Aug 17, 2026

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
Published on: November 5, 2021
Selective inhibition of Trypanosoma cruzi GAPDH by "bi-substrate" analogues
Sylvain Ladame1, Régis Fauré, Colette Denier
1University Chemical Laboratory, University of Cambridge, Cambridge CB2 1EW, UK. sl324@cam.ac.uk
Abstract:
A new series of "bi-substrate" analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.
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