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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Highly regio- and enantioselective thermal [2 + 2] cycloaddition of coumarin in a crystalline inclusion complex under
Yongqiang Wen1, Yanlin Song, Dongbo Zhao
1Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Abstract:
Coumarin and thiocoumarin, which are usually thermally unreactive for dimerization, were dimerized in their inclusion crystalline complexes under thermal and high vacuum conditions.
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