The effect of lipid peroxides and superoxide dismutase on systemic lupus erythematosus: a preliminary study

Serum lipid peroxide (LPO) levels, superoxide dismutase (SOD) activity in peripheral blood erythrocytes, serum ANA, anti-dsDNA, and C3 were measured in 83 patients with systemic lupus erythematosus (SLE) and in 29 healthy controls. Compared to the controls, LPO levels were significantly increased in active SLE patients while SOD activity was markedly decreased. From the active phase to the inactive phase, a gradual decline in LPO levels and an increase in SOD activity were observed. There was a close correlation between LPO levels and disease activity or the parameters including ANA titers, anti-DNA titers, and C3 levels; a significant negative correlation was found between SOD activity and LPO levels or these parameters. Further, a marked difference in SOD activity was found in untreated active cases with and without nephritis. As the SLE patients improved, LPO levels gradually declined and SOD activity increased. The present study indicates that free radicals and resultantly formed lipid peroxide levels are higher in patients with SLE than those in normal persons, probably contributing to the production of autoantibodies, nephritis, and vasculitis of other organs, and that excessively generated free radicals may play an important role in the pathogenesis of SLE, which is possibly due to diminished SOD activity.