Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive dysfunction after cardiac surgery: revisiting etiology.

Hilary P Grocott1, H Mayumi Homi, Ferenc Puskas

  • 1Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. h.grocott@duke.edu

Seminars in Cardiothoracic and Vascular Anesthesia
|May 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiopulmonary Bypass Effects on Minimum Alveolar Concentration and Other Bypass Terminology.

Anesthesia and analgesia·2026
Same author

Enhanced Recovery After Cardiac Surgery: Society of Cardiovascular Anesthesiologists (SCA) and American Society of Anesthesiologists (ASA) Membership Survey.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

The importance of dose on the onset of neuromuscular blockade for intubation in exsanguinating injuries.

The journal of trauma and acute care surgery·2026
Same author

Blood pressure management during cardiac surgery: a survey of Canadian cardiac anesthesiologists, perfusionists, and cardiac surgeons.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2025
Same author

Lowest Measured Temperature and Adverse Outcomes After Cardiac Surgery: Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Annals of surgery·2025
Same author

Cavoatrial Bypass for Cardiac Complications From Rosai-Dorfman Disease.

Annals of thoracic surgery short reports·2025

Cognitive dysfunction after cardiac surgery is common, with no effective treatments. Understanding the causes, like brain injury and inflammation, is key to developing new therapies.

Area of Science:

  • Neurology
  • Cardiology
  • Surgical Complications

Background:

  • Cognitive dysfunction is a common complication following cardiac surgery.
  • Current preventive and therapeutic options for post-cardiac surgery cognitive dysfunction are limited.
  • A deeper understanding of the underlying causes is crucial for developing effective interventions.

Purpose of the Study:

  • To review and detail the multifactorial etiologies of cognitive dysfunction after cardiac surgery.
  • To synthesize current evidence on the pathophysiology of cognitive impairment in this patient population.

Main Methods:

  • Literature review of studies investigating cognitive dysfunction after cardiac surgery.
  • Analysis of evidence supporting various etiological factors.

Related Experiment Videos

  • Synthesis of findings related to cerebral microembolization, hypoperfusion, inflammation, temperature changes, edema, and blood-brain barrier function.

    • Main Results:

    • Cognitive dysfunction is multifactorial, involving cerebral microembolization and global hypoperfusion.
    • Systemic and cerebral inflammation, temperature dysregulation, and cerebral edema contribute to cognitive impairment.
    • Genetic predispositions may influence patient susceptibility and recovery from neural injury.

    Conclusions:

    • The etiology of cognitive dysfunction post-cardiac surgery is complex and involves multiple interconnected pathways.
    • Further research into these specific etiological factors is essential for the development of targeted preventive and therapeutic strategies.