Related Experiment Video

Updated: Aug 17, 2026

In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

Cellular and molecular mechanisms of coronary vessel development

Hong Mu1, Ryuji Ohashi, Peter Lin

  • 1Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

Vascular Medicine (London, England)
|June 1, 2005
PubMed

Insights

Coronary vessel development is intricate, involving multiple cell types and molecular signals. Understanding these developmental pathways is crucial for advancing cardiovascular research and clinical applications.

Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Molecular mechanisms

Background:

  • Coronary vessel development involves vasculogenesis and angiogenesis, but not all cells originate from the heart.
  • Key stages include primordium generation, epicardial formation, mesenchymal cell development, and vascular plexus maturation.
  • This complex process is regulated by cell fate determination, migration, and epicardial-mesenchymal transformation.

Purpose of the Study:

  • To review the literature on coronary vessel development.
  • To discuss current advances and controversies in molecular and cellular mechanisms.
  • To direct future research in the field.

Main Methods:

  • Literature review of developmental biology studies.
  • Analysis of molecular and cellular mechanisms.
  • Discussion of current research findings and controversies.

Main Results:

  • Coronary system formation is a multi-step process involving distinct cellular origins and transformations.
  • Multiple molecular factors, including transcription factors, adhesion molecules, and growth factors, are critical.
  • Ongoing research continues to uncover complexities and address controversies in the field.

Conclusions:

  • Coronary vessel development is a highly regulated process with significant clinical implications.
  • Further investigation into molecular and cellular mechanisms is needed to advance cardiovascular research.
  • Understanding these pathways can guide future therapeutic strategies for heart conditions.

More Related Videos

Analysis of Coronary Vessels in Cleared Embryonic Hearts08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...