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[Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and
Qiong-hong Duan1, Zhi-gang Wang, Gui-bao Zhu
1The Department of Epidemiology, Tongji Medical College, Huazhong University of Science and Thenology, Wuhan 430030, China.
Objective:
To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.
Methods:
A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.
Results:
The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI: 1.14-2.13) and 0.78 (95% CI: 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.
Conclusion:
High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.
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