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Updated: Jan 13, 2026

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Tumour vascular targeting.

Dario Neri1, Roy Bicknell

  • 1Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland. dario.neri@pharma.ethz.ch

Nature Reviews. Cancer
|June 2, 2005
PubMed
Summary
This summary is machine-generated.

Targeting established tumor blood vessels offers a promising cancer therapy. This approach, known as vascular targeting, has shown effectiveness in animal models for treating solid tumors.

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Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Solid tumor growth relies on developing a blood supply.
  • Anti-angiogenic therapies aim to disrupt tumor vascularization.
  • Targeting established tumor vasculature presents new therapeutic opportunities.

Purpose of the Study:

  • To present evidence for vascular targeting as an antitumour strategy.
  • To describe methods for identifying tumor vascular targets.
  • To discuss the clinical prospects of vascular targeting.

Main Methods:

  • Review of evidence from animal models.
  • Description of strategies for identifying vascular targets.
  • Discussion of clinical applications.

Main Results:

  • Vascular targeting demonstrated effectiveness in preclinical animal models.
  • Strategies for identifying tumor vascular targets were outlined.
  • Future clinical applications were considered.

Conclusions:

  • Vascular targeting is a viable antitumour strategy.
  • Identification of specific targets is crucial for therapeutic development.
  • Further clinical research is warranted for vascular targeting therapies.