Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vigintiphobia revisited.

Jon F Watchko1

  • 1Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. jwatchko@mail.magee.edu

Pediatrics
|June 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Professor Dag Bratlid (1944-2025)-a tribute.

Pediatric research·2025
Same author

Identifying severe hypoalbuminemia in the newborn: a clinical priority for neonatologists.

Journal of perinatology : official journal of the California Perinatal Association·2025
Same author

Time to clarify the role of extrahepatic intestinal UGT1A1 in human neonatal bilirubin metabolism.

Pediatric research·2025
Same author

Revised World Health Organization (WHO) classification of G6PD gene variants: Relevance to neonatal hyperbilirubinemia.

Seminars in fetal & neonatal medicine·2025
Same author

Clarifying the Role of Serum Albumin in Hyperbilirubinemia Management.

Hospital pediatrics·2024
Same author

Universal cord blood screening for G6PD deficiency in Qatar.

Journal of perinatology : official journal of the California Perinatal Association·2024
Same journal

Severe Postoperative Hypernatremia in an Adolescent Following Sleeve Gastrectomy.

Pediatrics·2026
Same journal

Barriers to Implementing SMART for Asthma in Pediatric Primary Care.

Pediatrics·2026
Same journal

Blood Lead Testing Among Children Enrolled in Medicaid.

Pediatrics·2026
Same journal

From Screening to Support: Crafting Social Needs Response Systems That Work for Families.

Pediatrics·2026
Same journal

A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

Pediatrics·2026
Same journal

Pediatric Cheerleading-Related Head Injuries and the "Double Down" Rule Change.

Pediatrics·2026
See all related articles

This review examines the >20 mg/dL bilirubin exchange threshold for healthy term neonates. It hypothesizes that population and genetic factors may increase kernicterus risk in neonatal hyperbilirubinemia.

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology

Background:

  • The established threshold for exchange transfusion in term neonates is >20 mg/dL.
  • Recent kernicterus cases raise concerns about current management guidelines.

Purpose of the Study:

  • To revisit the evidence supporting the >20 mg/dL bilirubin exchange threshold.
  • To propose a hypothesis for the resurgence of kernicterus.

Main Methods:

  • Literature review of historical tenets and clinical research.
  • Analysis of population and genetic factors influencing neonatal hyperbilirubinemia.

Main Results:

  • The evidence for the >20 mg/dL threshold is re-evaluated.
  • A hypothesis links population/genetic factors to increased kernicterus risk.

Related Experiment Videos

Conclusions:

  • The current bilirubin exchange threshold may require reassessment.
  • Understanding genetic and population factors is crucial for preventing neonatal hyperbilirubinemia and kernicterus.