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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Recent advances in understanding pain mechanisms provide future directions for pain management
1Department of Physiological Nursing, University of California, San Francisco, USA. chris.miaskowski@nursing.ucsf.edu
Purpose/Objectives:
To review current knowledge of neurobiologic mechanisms that generate and maintain chronic pain and to explain how they might be applied in targeting treatment of chronic, inflammatory, and neuropathic pain syndromes.
Data Sources:
Published research, literature review articles, and abstracts as well as national statistics.
Data Synthesis:
Treatment for chronic pain associated with cancer and other syndromes remains suboptimal and falls significantly short of clinical needs. Data highlight the role that multiple neurobiologic mechanisms play in modulating and maintaining pain at various levels of the central and peripheral nervous systems. Novel agents have been developed that use a more targeted approach to treating chronic pain.
Conclusions:
A growing body of evidence highlights the critical role that neurobiologic mechanisms play in the initiation and maintenance of chronic pain. A thorough understanding of these mechanisms ultimately may result in targeted treatment approaches that focus on the central and peripheral mechanisms involved in mediation of chronic, inflammatory, and neuropathic pain syndromes.
Implications For Nursing:
A majority of patients undergoing active treatment for cancer experiences unrelieved pain. By gaining a better understanding of the mechanisms that generate and maintain chronic pain, oncology nurses can promote targeted pain management strategies that incorporate novel therapeutic agents.
Insights
Understanding chronic pain neurobiology is key to developing effective treatments. This review explores mechanisms for targeted therapies in chronic, inflammatory, and neuropathic pain.
Area of Science:
- Neuroscience
- Pain Research
- Pharmacology
Background:
- Chronic pain, including cancer-related pain, affects a significant patient population.
- Current treatments for chronic pain remain suboptimal, failing to meet clinical needs.
- Multiple neurobiologic mechanisms at central and peripheral levels modulate and maintain pain.
Purpose of the Study:
- To review current knowledge of neurobiologic mechanisms in chronic pain.
- To explore the application of this knowledge in targeted treatment strategies.
- To address chronic, inflammatory, and neuropathic pain syndromes.
Main Methods:
- Review of published research, literature reviews, and abstracts.
- Inclusion of national statistics on pain prevalence and treatment outcomes.
- Synthesis of data on neurobiologic pain mechanisms.
Main Results:
- Chronic pain treatment is suboptimal, with significant unmet clinical needs.
- Neurobiologic mechanisms at central and peripheral nervous system levels are crucial for pain modulation and maintenance.
- Novel therapeutic agents targeting specific mechanisms have been developed.
Conclusions:
- Growing evidence supports the critical role of neurobiologic mechanisms in chronic pain initiation and maintenance.
- Understanding these mechanisms can lead to targeted treatment approaches.
- Oncology nurses can utilize this knowledge for improved pain management strategies with novel agents.
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