Related Experiment Video
Updated: Aug 17, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
Published on: February 10, 2012
Role of magnetic resonance imaging in visualizing coronary arteries
Sumeesh Dhawan1, Kodlipet C Dharmashankar, Tahir Tak
1Department of Internal Medicine, Marshfield Clinic, Marshfield, Wisconsin, USA.
Insights
Coronary magnetic resonance angiography (MRA) offers noninvasive visualization of coronary arteries but requires further research to improve diagnostic accuracy and resolution for clinical use in diagnosing ischemic heart disease.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Ischemic heart disease is a leading global cause of mortality.
- Conventional coronary angiography, the current gold standard, is invasive and carries risks.
- Existing noninvasive tools lack direct visualization and quantification of coronary stenoses.
Purpose of the Study:
- To review studies comparing coronary MRA with conventional angiography.
- To discuss current 2D and 3D coronary MRA techniques and their limitations.
- To highlight the potential of coronary MRA as a noninvasive diagnostic tool.
Main Methods:
- Review of existing literature comparing coronary MRA and conventional coronary angiography.
- Discussion of current two-dimensional and three-dimensional coronary MRA techniques.
- Analysis of the limitations of coronary MRA.
Main Results:
- Coronary MRA allows noninvasive visualization of coronary arteries.
- Coronary MRA has not yet achieved routine clinical practice status.
- Limitations in diagnostic resolution and accuracy currently exist for coronary MRA.
Conclusions:
- Coronary MRA shows promise as a noninvasive diagnostic tool for coronary artery disease.
- Further research is essential to enhance the diagnostic resolution and accuracy of coronary MRA.
- Improvements are needed for coronary MRA to be widely adopted in clinical practice.
Abstract:
Ischemic heart disease is the leading cause of death worldwide. At present, coronary angiography is the gold standard for the diagnosis of coronary artery disease. Conventional coronary angiography is an invasive procedure with a small, yet inherent risk of myocardial infarction, stroke, potential arrhythmias, and death. Other noninvasive diagnostic tools, such as electrocardiography, echocardiography, and nuclear imaging are now widely available but are limited by their inability to directly visualize and quantify coronary artery stenoses and predict the stability of plaques. Coronary magnetic resonance angiography (MRA) is a technique that allows visualization of the coronary arteries by noninvasive means; however, it has not yet reached a stage where it can be used in routine clinical practice. Although coronary MRA is a potentially useful diagnostic tool, it has limitations. Further research should focus on improving the diagnostic resolution and accuracy of coronary MRA. This review summarizes results from several studies comparing coronary MRA with conventional coronary angiography. Current two-dimensional and three-dimensional coronary MRA techniques and their limitations are also discussed.
Related Concept Videos
Magnetic Resonance Imaging
Imaging Studies for Cardiovascular System IV: CMRI
Imaging Studies for Cardiovascular System V: CT
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies IV: Magnetic Resonance Imaging
