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Updated: Aug 17, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
A simple and efficient copper-catalyzed procedure for the hydrosilylation of hindered and functionalized ketones
Silvia Díez-González1, Harneet Kaur, Fabiano Kauer Zinn
1Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
Abstract:
The catalytic hydrosilylation of highly hindered and functionalized ketones is described. The combination of inexpensive catalyst precursors, CuCl and NHC.HX (NHC = N-heterocyclic carbene), leads to a highly efficient reduction mediator for the preparation of silyl ethers from unfunctionalized and functionalized alkyl, cyclic, bicyclic, aromatic, and heteroaromatic ketones. A series of catalyst precursors have been structurally characterized and a catalyst-structure activity relationship is discussed.
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