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Increased CSF/serum albumin ratio: a recurrent finding in violent offenders
H Anckarsäter1, A Forsman, K Blennow
1Longitudinal Clinical Psychiatry, Institute of Clinical Sciences, Malmö, Sweden. henrik.anckarsater@skane.se
Objective:
To test the hypothesis that cerebrospinal fluid (CSF)/ serum albumin ratios are increased in violent offenders.
Subjects And Methods:
In a previous study of violent offenders, we found significantly higher CSF/serum album ratios (as a sign of increased blood-brain barrier permeability) in violent offenders than in healthy controls. For the present replication study, we recruited a new group of 28 violent offenders, aged 45 years or younger, and 20 new control subjects.
Results:
The albumin ratio was again significantly higher in the offender group (mean 6.2) than in the control group (mean 4.6) (P = 0.012). Substance abuse or current medication did not appear to explain this finding.
Conclusion:
Increased CSF/serum albumin ratios are an unspecific sign of neurological dysfunction in subgroups of violent offenders.
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