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PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes
Swanand P Gore1, David F Burke, Tom L Blundell
1Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. swanand@cryst.bioc.cam.ac.uk
Summary:
Voronoi tessellation has proved to be a useful tool in protein structure analysis. We have developed PROVAT, a versatile public domain software that enables computation and visualization of Voronoi tessellations of proteins and protein complexes. It is a set of Python scripts that integrate freely available specialized software (Qhull, Pymol etc.) into a pipeline. The calculation component of the tool computes Voronoi tessellation of a given protein system in a way described by a user-supplied XML recipe and stores resulting neighbourhood information as text files with various styles. The Python pickle file generated in the process is used by the visualization component, a Pymol plug-in, that offers a GUI to explore the tessellation visually.
Availability:
PROVAT source code can be downloaded from http://raven.bioc.cam.ac.uk/~swanand/Provat1, which also provides a webserver for its calculation component, documentation and examples.
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