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Evaluation of chemically sensitive patients.

N Fiedler1, C Maccia, H Kipen

  • 1Department of Environmental and Community Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854.

Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
|May 1, 1992
PubMed
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This study rigorously defines multiple chemical sensitivities (MCS) and finds no significant immunological issues in patients. Some patients showed mild verbal memory deficits but no history of psychiatric disorders.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Immunology

Background:

  • Growing patient reports link symptoms to low-level chemical exposures, termed multiple chemical sensitivities (MCS).
  • Previous research on MCS patients lacked rigorous selection criteria, potentially affecting study validity.

Purpose of the Study:

  • To apply a rigorous definition of MCS for patient selection in a comprehensive health evaluation.
  • To investigate the medical, psychiatric, neuropsychological, and immunological status of MCS patients.

Main Methods:

  • Utilized a strict definition to recruit patients diagnosed with multiple chemical sensitivities.
  • Conducted thorough medical, psychiatric, neuropsychological, and immunological assessments.

Main Results:

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  • Patients selected via rigorous criteria showed no significant immunological abnormalities.
  • Neuropsychological testing revealed no widespread deficits, except for consistent poor performance on one verbal memory test.
  • Unlike some prior studies, participants generally lacked a history of psychiatric disorders, though some exhibited current depression.

Conclusions:

  • Rigorous patient selection in MCS research is crucial for accurate health status assessment.
  • Findings suggest that MCS may not be primarily linked to immunological dysfunction.
  • Further investigation into specific cognitive functions, like verbal memory, in MCS patients is warranted.