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STR-genotyping from human medieval tooth and bone samples.

François-Xavier Ricaut1, Christine Keyser-Tracqui, Eric Crubézy

  • 1Laboratoire d'Anthropologie Moléculaire, Institut de Médecine Légale, 11 rue Humann, 67085 Strasbourg Cedex, France. fx.ricaut@infonie.fr

Forensic Science International
|June 7, 2005
PubMed
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Ancient DNA from 10 skeletons was analyzed using autosomal short tandem repeats (STRs). Tooth samples yielded better DNA preservation than bone, and a purification protocol removed PCR inhibitors.

Area of Science:

  • Paleogenetics
  • Forensic Science
  • Archaeology

Background:

  • Analysis of ancient DNA (aDNA) from skeletal remains provides insights into past populations.
  • The Gravette site in southern France offers a unique window into the 400-1000 AD period.

Observation:

  • DNA was extracted from bone and tooth samples of 10 skeletons.
  • Ancient DNA was analyzed using autosomal short tandem repeats (STRs).
  • DNA in ancient remains was highly degraded, with tooth samples showing better preservation than bone.

Findings:

  • DNA extracted from ancient dental pulp contained polymerase chain reaction (PCR) inhibitors, likely due to extreme fragmentation.
  • An adapted DNA extraction protocol incorporating an additional purification step successfully removed these PCR inhibitors.

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Implications:

  • Improved DNA extraction methods enhance the reliability of ancient DNA analysis from challenging samples.
  • This research contributes to understanding ancient population genetics and improving forensic techniques for degraded DNA.