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Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
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Multiple branch retinal arteriolar occlusions associated with smallpox vaccination
Gennady Landa1, Arie Marcovich, Hana Leiba
1Department of Ophthalmology, Kaplan Medical Center, 76100 Rehovot, Israel. genal@inter.net.il
The Journal of Infection
|June 7, 2005
Summary
A rare case of multiple branch retinal arteriolar occlusions and encephalopathy occurred in a man after smallpox vaccination. Treatment led to significant visual and neurological recovery.
Area of Science:
- Ophthalmology
- Neurology
- Immunology
Background:
- Smallpox vaccination can rarely trigger neurological and ocular complications.
- Branch retinal arteriolar occlusions (BRAO) are typically associated with vascular risk factors.
Observation:
- A 53-year-old physician developed sudden visual field loss post-vaccination.
- Clinical examination revealed retinal infarcts, cotton wool spots, and white matter brain lesions.
Findings:
- Diagnostic angiography confirmed multiple BRAOs and non-perfused areas.
- Brain MRI showed focal white matter lesions, indicative of encephalopathy.
Implications:
- This case highlights a potential link between smallpox vaccination and BRAO with encephalopathy.
- Prompt treatment with corticosteroids and immunoglobulins may improve outcomes in such rare events.
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