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Related Experiment Videos

Antimicrobial terpenoids from Pterocarpus indicus.

Consolacion Y Ragasa1, Roderick D De Luna, Joy G Hofilena

  • 1Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines. sagasac@dlsu.edu.ph

Natural Product Research
|June 9, 2005
PubMed
Summary

Pterocarpus indicus leaves yielded loliolide and paniculatadiol, showing moderate antifungal activity against Candida albicans. Flower extracts contained lupeol and phytol esters, with limited antimicrobial effects observed.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Microbiology

Background:

  • Pterocarpus indicus is a plant species known for its potential medicinal properties.
  • Investigating the chemical constituents of Pterocarpus indicus can lead to the discovery of novel bioactive compounds.
  • Natural products are a rich source of antimicrobial agents.

Purpose of the Study:

  • To isolate and characterize chemical compounds from the leaves and flowers of Pterocarpus indicus.
  • To evaluate the antimicrobial activity of the isolated compounds and their mixtures.

Main Methods:

  • Extraction of plant materials using ethyl acetate.
  • Purification of compounds using silica gel chromatography.
  • Structure elucidation of isolated compounds via Nuclear Magnetic Resonance (NMR) spectroscopy.

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  • Antimicrobial susceptibility testing against various bacterial and fungal strains.

    • Main Results:

    • A mixture of loliolide (predominantly) and paniculatadiol was isolated from leaf extract.
    • Lupeol and phytol esters were obtained from flower extract.
    • The loliolide/paniculatadiol mixture exhibited moderate activity against Candida albicans.
    • Low activity was observed against Pseudomonas aeruginosa, Escherichia coli, and Aspergillus niger.
    • The mixture was inactive against Staphylococcus aureus, Bacillus subtilis, and Trichophyton mentagrophytes.

    Conclusions:

    • Pterocarpus indicus contains loliolide, paniculatadiol, lupeol, and phytol esters.
    • The isolated loliolide and paniculatadiol mixture possesses moderate antifungal properties, particularly against Candida albicans.
    • Further research may explore the potential of these compounds as antimicrobial agents.