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Natural product-like libraries based on non-aromatic, polycyclic motifs
Roland Messer1, Cyril A Fuhrer, Robert Häner
1Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
Current Opinion in Chemical Biology
|June 9, 2005
Summary
Diversity-oriented synthesis creates diverse compounds, often inspired by natural products. This review highlights libraries featuring non-aromatic, polycyclic structures found in nature, offering unique chemical scaffolds.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Natural Product Chemistry
Background:
- Many drugs and lead compounds are derived from natural sources.
- Natural products often possess complex, non-aromatic, polycyclic core structures.
- These structures offer geometric definition and potential for high functional specialization.
Purpose of the Study:
- To review current examples of combinatorial libraries.
- To focus on libraries that mimic natural products.
- To highlight libraries based on non-aromatic, polycyclic motifs.
Main Methods:
- Literature review of diversity-oriented synthesis strategies.
- Analysis of combinatorial libraries inspired by natural products.
- Identification of libraries featuring non-aromatic polycyclic structures.
Main Results:
- Several examples of natural product-like libraries were identified.
- These libraries incorporate non-aromatic, polycyclic motifs.
- The synthesis approaches are based on naturally occurring compounds.
Conclusions:
- Diversity-oriented synthesis is effective for exploring chemical space.
- Natural product-inspired scaffolds, particularly non-aromatic polycycles, are valuable for library design.
- These libraries offer promising starting points for drug discovery.