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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Wanted: new multicomponent reactions for generating libraries of polycyclic natural products
Agnieszka Ulaczyk-Lesanko1, Dennis G Hall
1Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Abstract:
The amalgamation of two of combinatorial chemistry's most attractive concepts--natural product libraries and multicomponent reactions (MCRs)--should provide a powerful tactic for generating libraries of bioactive compounds. Yet, despite many recent advances in this area, only a few MCRs can deliver functionalized products whose structures closely resemble that of complex polycyclic natural products. A large proportion of recently developed MCRs are based on [4+2] or [3+2] cycloadditions, and isocyanide-based processes. Because of substrate limitations, however, they are not always ideally suitable for applications in diversity-oriented synthesis of natural product-like compounds. A promising area awaiting further development is the use of transition metal-catalyzed cascade reactions.
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