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Updated: Feb 26, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Uncovering the Reactivity of Direct Photoredox Catalyzed α-C-H Alkylation of Alcohols: A Boron-Free Procedure
Geneviève F O'Keefe1, Dennis G Hall1
1Department of Chemistry, University of Alberta, Centennial Centre for Interdisciplinary Science, Edmonton, AB T6G 2G2, Canada.
Abstract:
Alcohol functionalization is an important class of pharmaceutically relevant transformations that have increasingly been achieved through photoredox-hydrogen atom transfer catalysis. Many methods rely on exogenous bond-weakening activators such as boron-based catalysts. Herein, a reported hemiboronic acid catalyst was shown to dynamically interact with alcohols, however, with no effect on the efficiency or stereoselectivity of the α-C-H alkylation of alcohols. A simplified procedure affords products in yields of 18-95% without a boron cocatalyst.
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