Related Experiment Video
Updated: Aug 17, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
Published on: September 27, 2018
Pathophysiological roles of ectopic tachygastria induced with antral electrical stimulation
Hongbing Zhu1, Hui Ouyang, J D Z Chen
1Veterans Administration Research Foundation, Oklahoma City, OK, USA.
Aim:
To investigate the pathophysiological roles of tachygastria using antral electrical stimulation (AES).
Methods:
The study was performed on 13 healthy female hound-type dogs chronically implanted with three pairs of serosal electrodes and a gastric cannula (n = 7). In the first experiment (n = 7), the antral motility was measured for three 30-min periods right after a solid meal. AES was performed during the second 30-min period at a tachygastric frequency. In the second experiment (n = 6), gastric slow waves and animal behavior were monitored in the fasting state at baseline and with various parameters of AES.
Results:
(1) AES at tachygastric frequencies (7-14 cpm) significantly reduced the percentage of normal 4- to 6-cpm slow waves and induced tachygastria; (2) AES significantly and substantially inhibited the antral motility in the fed state; (3) AES in the fasting state energy dependently induced symptoms, and the symptom score was linearly correlated with the stimulation frequency, and (4) there was a significant negative correlation between percentage of tachygastria and index of antral motility.
Conclusions:
AES induces tachygastria and inhibits the antral motility. Tachygastria is correlated with antral motility.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Esophageal Achalasia
Gastric Motility
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Pyloric Obstruction
Mechanism of Cardiac Arrhythmias
Dysrhythmias III: Characteristics of Dysrhythmias
