Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probiotics used in human studies.

David C Montrose1, Martin H Floch

  • 1Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. montrose@student.uchc.edu

Journal of Clinical Gastroenterology
|June 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary Protein Source Mediates Colitis Pathogenesis Through Bacterial Modulation of Bile Acids.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
Same author

Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms.

Molecular cancer therapeutics·2025
Same author

Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids.

bioRxiv : the preprint server for biology·2025
Same author

A Comprehensive Metabolomic and Microbial Analysis Following Dietary Amino Acid Reduction in Mice.

Metabolites·2024
Same author

Metabolic regulation of the mitochondrial immune checkpoint.

Oncoimmunology·2024

Probiotic research between 1980 and 2004 shows many studies used single or multiple organisms for various conditions. While many studies reported positive results, further evaluation is needed.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Probiotics, defined as live microorganisms conferring a health benefit, have been investigated for various human diseases.
  • Understanding the landscape of probiotic research is crucial for guiding future studies and clinical applications.

Purpose of the Study:

  • To systematically review the scientific literature from 1980 to 2004.
  • To identify the types of studies, probiotic organisms, and dosages employed in human probiotic research.
  • To analyze the reported outcomes, both positive and negative, of probiotic interventions.

Main Methods:

  • A comprehensive literature search was conducted using PubMed for studies published between 1980 and August 2004.
  • Data extraction included probiotic organisms used, dosage, administration vehicle, frequency, and reported results.

Related Experiment Videos

  • A total of 185 relevant manuscripts were identified and analyzed.

    • Main Results:

    • Of the 185 studies, 125 utilized single probiotic organisms, while 60 employed multiple organisms (2-9 strains).
    • Investigators reported a total of 288 clinical conclusions, with 239 indicating positive outcomes and 49 indicating negative outcomes.
    • The reviewed literature encompasses a wide array of probiotic strains, dosages, and clinical applications.

    Conclusions:

    • A substantial body of literature exists in peer-reviewed journals demonstrating potential benefits of probiotic administration.
    • The reviewed studies utilized diverse probiotic formulations and were applied across numerous clinical scenarios.
    • Most studies are observational or simple reports, highlighting a need for more rigorous, well-designed clinical trials to confirm efficacy.