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Published on: September 15, 2023
In the current era, complete revascularization improves survival after coronary artery bypass surgery
Thomas Kleisli1, Wen Cheng, Milagros J Jacobs
1Division of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, Calif, USA.
Insights
Complete revascularization in coronary bypass grafting significantly improves 5-year survival rates. Arterial grafting also enhances outcomes, while off-pump techniques do not impact survival. Achieving complete revascularization is crucial for better patient prognosis.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Cardiac Surgery
Background:
- Complete revascularization is the traditional standard in coronary bypass grafting.
- Surgical techniques are evolving with increased use of arterial conduits and off-pump procedures.
Purpose of the Study:
- To evaluate the impact of complete versus incomplete revascularization on long-term survival after coronary bypass grafting.
- To assess the influence of arterial conduits and off-pump techniques on patient outcomes.
Main Methods:
- A cohort of 1034 patients undergoing non-redo bypass surgery between 1998 and 2000 were followed.
- Incomplete revascularization was defined as the absence of grafts to territories with >=50% stenosis.
- Data collected via questionnaires and telephone contact, with follow-up averaging 3.3 years.
Main Results:
- Incomplete revascularization occurred in 9.4% of patients and was more common in off-pump (21.7%) versus on-pump (6.3%) procedures.
- Incomplete revascularization, cerebrovascular accidents, and COPD predicted increased cardiac death risk.
- Arterial grafting (LITA, RITA, radial artery) significantly reduced cardiac death risk.
- 5-year survival was 82.4% with complete revascularization vs. 52.6% with incomplete revascularization (P < .001).
Conclusions:
- Complete revascularization and arterial grafting are associated with improved 5-year survival.
- Off-pump techniques do not appear to affect survival rates.
- Complete revascularization should be prioritized in bypass grafting whenever feasible.
Background:
Complete revascularization has been the standard for coronary bypass grafting. However, surgical intervention has evolved with increasing use of arterial conduits and off-pump techniques.
Methods:
Patients undergoing non-redo bypass surgery from January 1998 through December 2000 were followed up with questionnaires and telephone contact. Incomplete revascularization was defined as absence of bypass grafts placed to a coronary territory supplied by a vessel with 50% or greater stenosis.
Results:
One thousand thirty-four patients were followed for a mean of 3.3 +/- 1.6 years. Complete revascularization was found in 937 (90.6%) patients, and incomplete revascularization was found in 97 (9.4%) patients. Eight hundred twenty-seven (80.4%) patients underwent on-pump operations, and 207 (19.6%) underwent off-pump operations. Incomplete revascularization was more prevalent in off-pump versus on-pump operations (21.7% vs 6.3%, P < .001). Multivariable Cox regression analysis indicated that in-hospital cerebrovascular accidents (hazard ratio, 5.49; P < .001), chronic obstructive pulmonary disease (hazard ratio, 1.97; P = .019), and incomplete revascularization (hazard ratio, 1.85; P = .040) predicted an increased hazard (risk) of cardiac death. Left internal thoracic artery (hazard ratio, 0.38; P = .047), right internal thoracic artery (hazard ratio, 0.25; P = .019), and radial artery (hazard ratio, 0.36; P < .001) grafting reduced the risk of cardiac death. The 5-year unadjusted survival rate was 52.6% versus 82.4% in patients undergoing incomplete and complete revascularization ( P < .001), with cardiac survival rates of 74.5% versus 93.1%, respectively ( P < .001). However, this difference in cardiac survival was smaller in octogenarians with incomplete versus complete revascularizations (77.4% vs 87.6%, P = .101) and was essentially absent in off-pump versus on-pump operations if complete revascularization was achieved in both cases (93.6% vs 93.1%, P > .200).
Conclusions:
Complete revascularization and arterial grafting improve 5-year survival. Off-pump techniques do not affect survival. Complete revascularization should be performed whenever possible.
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