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[Arsenical keratoses and carcinomas].

I Fumal1, C Piérard-Franchimont, G E Piérard

  • 1CHR hutois, Service de Dermatologie, Huy.

Revue Medicale De Liege
|June 10, 2005
PubMed
Summary

Chronic arsenicism can manifest with skin conditions like palmo-plantar keratoses and Bowen's disease, signaling increased cancer risk. Early recognition of these cutaneous signs is crucial for identifying internal malignancies and managing patient risk.

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Area of Science:

  • Dermatology
  • Oncology
  • Toxicology

Background:

  • Chronic arsenic exposure is a known risk factor for various cancers.
  • Cutaneous manifestations of arsenicism, though less common now, serve as important diagnostic indicators.
  • Identifying past arsenic exposure is critical for comprehensive patient assessment.

Observation:

  • A 70-year-old male presented with classic signs of chronic arsenicism: palmo-plantar keratoses and Bowen's disease.
  • The patient subsequently developed multiple basal cell carcinomas and invasive squamous cell carcinomas.
  • A pulmonary malignancy with cerebral metastases was also diagnosed.

Findings:

  • The case highlights the association between chronic arsenicism and the development of multiple skin cancers.
  • Cutaneous lesions associated with arsenic exposure can precede or coincide with internal malignancies.
  • This case underscores the importance of recognizing dermatological signs to uncover underlying arsenic etiology.

Implications:

  • Recognizing cutaneous warning signs of arsenicism is vital for early detection of internal cancers.
  • Dermatologists and oncologists should consider arsenic exposure in patients with unexplained skin and internal malignancies.
  • Prompt identification of arsenicism can lead to timely intervention and improved patient outcomes regarding overall cancer risk.

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