Electrophysiological studies on galanin effects in brain--progress during the last six years

The effects of galanin and galanin fragments have been studied on neurons in various brain regions of rodents using electrophysiological techniques. Here, we mainly review reports published during the last six years, that is after the second galanin symposium in 1998. These papers deal with locus coeruleus (LC), the hippocampal formation (HF), hypothalamus, the nucleus of the diagonal band of Broca (DBB) and the dorsal vagal complex (DVC). In most cases galanin has an inhibitory effect by increasing a potassium conductance or reducing a calcium conductance. In LC, beside a direct inhibitory effect, galanin exerts an indirect effect enhancing the noradrenaline-induced hyperpolarization. In the HF, galanin (1-15), but not galanin (1-29), induces hyperpolarization in CA3 pyramidal neurons. Inhibitory effects of galanin on several forms of synaptic plasticity including long-term potentiation, frequency facilitation and paired-pulse facilitation have also been demonstrated in normal and transgenic animals. In the hypothalamic arcuate nucleus galanin has a presynaptic action inhibiting glutamate release, as well as a postsynaptic effect via the galanin R1 receptor. In the DVC, galanin inhibits dorsal vagal motor neurons projecting to the stomach by activation of a postsynaptic galanin receptor. However, excitatory effects of galanin have also been reported in several regions, such as the DBB nucleus, where galanin increases excitability by decreasing a K+ conductance. Taken together, electrophysiological studies have further supported the role of galanin as a neurotransmitter/neuromodulator in the brain.