Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope.

Julia L Newton1, Peter Donaldson, Steve Parry

  • 1Cardiovascular Investigation Unit (Institute for Ageing and Health), Care of the Elderly Offices, Royal Victoria Infirmary, University of Newcastle, Newcastle NE1 4LP, United Kingdom. julianewton@blueyonder.co.uk

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|June 10, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'I Didn't Even Associate the Two Together at All': A Qualitative Study of 'Information Work' Undertaken by Parents and Their Children With Epilepsy to Make Sense of Sleep and Seizures.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Patient and Public Involvement around the world: where we are and where Brazilian research needs to go.

Brazilian journal of physical therapy·2026
Same author

MPXV replication and drug resistance in CNS of advanced HIV case at autopsy.

Research square·2026
Same author

Prophylactic antibiotics to prevent chest infections in children with neurological impairment: the PARROT RCT.

Health technology assessment (Winchester, England)·2026
Same author

Insect in the Ear-Response and Treatment of an Uncommon Prehospital Emergency: A Case Report.

Clinical practice and cases in emergency medicine·2026
Same author

Randomised controlled trial of online behavioural sleep intervention for children with epilepsy.

Scientific reports·2026

Genetic factors may influence vasovagal syncope (VVS). This study found no association between the ACE gene and VVS risk, suggesting other genetic causes may be involved in this condition.

Area of Science:

  • Cardiovascular Genetics
  • Human Genetics

Background:

  • Vasovagal syncope (VVS) exhibits a notable heritable component, suggesting a potential genetic basis for some cases.
  • Previous research indicates a significant sibling relative risk (lambda(s): 1080) for VVS.

Purpose of the Study:

  • To investigate the potential genetic contribution of the Angiotensin-Converting Enzyme (ACE) insertion/deletion polymorphism to vasovagal syncope.
  • To examine the association between ACE gene variants and VVS risk through case-control and family-based association studies.

Main Methods:

  • DNA was collected from 165 VVS patients and 114 of their first-degree relatives.
  • Genotyping for the ACE insertion/deletion polymorphism was performed.
  • Case-control analysis compared VVS patients with a large national control population (>6000 subjects).

Related Experiment Videos

  • Family-based association tests assessed allele transmission.

    • Main Results:

    • No significant differences in ACE insertion or deletion allele frequencies were observed between VVS cases and the control population.
    • Family-based association studies did not reveal preferential transmission of ACE alleles to affected individuals (P=0.1789).

    Conclusions:

    • Polymorphisms in the ACE gene alone are not associated with an increased risk of vasovagal syncope.
    • Further research is warranted to explore other candidate genes and clarify the genotype-phenotype relationship in VVS.