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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Inflammatory biomarkers and statins
Luis Miguel Blanco-Colio1, José Tuñón, José Luis Martín-Ventura
1Vascular Research Lab, Department of Cardiology, Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
Insights
Atherosclerosis is an inflammatory disease. This review examines inflammatory markers like C-reactive protein (CRP) and their modulation by statins, offering insights into cardiovascular disease prevention and treatment.
Area of Science:
- Cardiovascular Medicine
- Inflammation Research
- Pharmacology
Background:
- Atherosclerosis is increasingly understood as an inflammatory disorder.
- Elevated inflammatory molecules are observed in individuals at high risk for acute coronary events.
Purpose of the Study:
- To review current inflammatory markers for atherosclerosis.
- To explore the therapeutic modulation of these markers, particularly by HMG-CoA reductase inhibitors (statins).
Main Methods:
- Analysis of circulating levels of inflammatory markers.
- Review of therapeutic interventions, focusing on statins.
- Discussion of emerging technologies for marker discovery.
Main Results:
- Key inflammatory markers analyzed include C-reactive protein (CRP), CD40 ligand, adhesion molecules, and chemokines.
- Statins show potential in modulating these inflammatory markers.
- Future technologies promise discovery of new diagnostic and prognostic markers.
Conclusions:
- Inflammatory markers play a crucial role in atherosclerosis.
- Statins offer a therapeutic avenue for modulating inflammation in cardiovascular disease.
- Advanced technologies will enhance the identification of novel biomarkers for improved cardiovascular disease management.
Abstract:
The concept of atherosclerosis as an inflammatory disorder has led to the exploration of new pathogeneses of this disease. In this regard, the levels of several inflammatory molecules are frequently increased in subjects at high risk of developing an acute coronary event. With a simple analysis we can characterize the circulating levels of a marker and its therapeutic modulation with various drugs. In this review we have analyzed different inflammatory markers currently used, such as C-reactive protein (CRP), CD40 ligand, adhesion molecules and chemokines, and their possible modulation by therapeutic intervention with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Moreover, in the future, new technologies will allow us to discover new markers, or sets of them, that could indicate the direction to be taken in the prevention and treatment of cardiovascular diseases.
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