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[Xanthium spinosum L.--a phytochemical study].

J Klecáková-Karlícková1, L Jahodár

  • 1Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické botaniky a ekologie. jana.karlickova@faf.cuni.cz

Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
|June 11, 2005
PubMed
Summary
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This study isolated atractyloside, xanthanolide derivatives, and phytosterols from Xanthium spinosum L. These compounds were analyzed for their biological activity and toxicity using the Tubifex tubifex test.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Product Chemistry

Context:

  • Xanthium spinosum L. is a plant found in local flora.
  • The biological activity and toxicity of this plant have not been previously studied.
  • Bioassay-guided separation is a key methodology.

Purpose:

  • To isolate and identify chemical constituents from Xanthium spinosum L.
  • To determine the biological activity (toxicity) of the isolated compounds.
  • To establish a phytochemical profile for Xanthium spinosum L.

Summary:

  • Isolation of ent-kaurane diterpene atractyloside from methanol extract of aerial parts.
  • Isolation of xanthumin and deacetylxanthumin (xanthanolide derivatives) from acetone extract of aerial parts.

Related Experiment Videos

  • Isolation of phytosterols (beta-sitosterol, stigmasterol) and fatty acids from ethanol and acetone extracts, respectively.

    • Impact:

    • Provides the first detailed phytochemical and toxicological analysis of Xanthium spinosum L.
    • Identifies specific bioactive compounds with potential pharmacological relevance.
    • Establishes a foundation for further research into the medicinal applications and safety of Xanthium spinosum L.