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Antibody detection using pooled sera and a solid phase system.

M J Beck1, J T Hardman, A M Briseño

  • 1Community Blood Center, 4040 Main, Kansas City, MO 64111, USA.

Immunohematology
|January 1, 1991
PubMed
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The Immucor Capture-R solid phase system is a feasible alternative for routine donor antibody screening. This method demonstrated comparable results to the traditional procedure, ensuring reliable antibody detection in pooled donor sera.

Area of Science:

  • Transfusion Medicine
  • Immunoserology

Background:

  • Routine donor antibody screening is crucial for blood transfusion safety.
  • Evaluating alternative methods can optimize laboratory efficiency and accuracy.

Purpose of the Study:

  • To assess the feasibility of using the Immucor Capture-R solid phase (SP) system for donor antibody screening.
  • To compare the SP system's performance against the established routine procedure (RP).

Main Methods:

  • The Immucor Capture-R SP system was evaluated, adapting manufacturer protocols for pooled donor sera.
  • Parallel testing compared SP results with the RP, which utilized a 12-drop pool of donor sera and indirect antiglobulin testing.
  • Testing included 888 donor pools and 70 stored sera with known alloantibodies.

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Main Results:

  • The SP system yielded results comparable to the RP in parallel testing.
  • Post-implementation testing of 1,135 donor pools showed satisfactory performance of the SP system.
  • No significant discrepancies were noted when comparing SP results to historical data.

Conclusions:

  • The Immucor Capture-R system is a viable and effective method for antibody detection in pooled donor sera.
  • The SP system offers a reliable alternative to traditional methods for donor antibody screening.
  • Implementation of the SP system appears satisfactory for routine blood bank operations.