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Related Experiment Videos

Cocaine enhances one-way avoidance responding in mice.

S B Weinberger1, C A Riedel, P H Janak

  • 1Department of Psychology, University of California, Berkeley 94720.

Pharmacology, Biochemistry, and Behavior
|April 11, 1992
PubMed
Summary

Posttraining cocaine injections improve avoidance learning in mice, similar to rats. This effect is specific to cocaine and not due to its local anesthetic properties or peripheral actions.

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Animal Models

Background:

  • Previous studies demonstrated that posttraining cocaine administration enhances avoidance learning in rats.
  • The current study investigates if this enhancement is specific to rats or a broader phenomenon across species.

Purpose of the Study:

  • To determine the species generality of cocaine's enhancement of avoidance learning.
  • To investigate the effects of posttraining cocaine injection on a one-way active avoidance response in mice.

Main Methods:

  • Mice received cocaine (30 mg/kg, IP) immediately after two escape-only trials on day 1.
  • Avoidance response performance was assessed on day 2.
  • Control groups received equimolar doses of lidocaine or cocaine methiodide.

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Main Results:

  • Cocaine administration significantly enhanced subsequent avoidance response performance in mice.
  • Neither lidocaine nor cocaine methiodide affected avoidance performance.
  • These findings suggest the effect is not due to local anesthetic properties or peripheral mediation.

Conclusions:

  • Cocaine enhances avoidance learning in mice, indicating species generality.
  • The observed effect is likely mediated by central mechanisms, not peripheral actions or local anesthesia.