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Updated: Aug 17, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland
Miguel García-González1, Ihab Abdulkader, Angel Vázquez Boquete
1Department of Nephrology, Hospital Clínico Universitario, Choupana s/n, 15706, Santiago de Compostela, Spain.
Abstract:
This study was undertaken to investigate cyclooxygenase-2 (COX-2) expression in follicular cells of the human thyroid. COX-2 expression was studied immunohistochemically in a total of 174 samples. COX-2 immunoreactivity was confined to the cell cytoplasm with the nuclei remaining unlabelled. COX-2 expression was observed in five cases (17.2%) of normal follicular cells and in one case (16.6%) of solid cell nests. Follicular carcinoma expressed COX-2 more frequently than follicular adenoma (93.4% vs 21.1%) (p
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