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Oestrogen functions in skin and skin appendages

M J Thornton1

  • 1Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK. M.J.Thornton@bradford.ac.uk

Expert Opinion on Therapeutic Targets
|June 14, 2005
PubMed

Insights

Oestrogens significantly impact skin physiology by affecting cells like keratinocytes and melanocytes, and modulating skin appendages. They influence skin aging, pigmentation, and cancer through distinct cellular receptors and signaling pathways.

Area of Science:

  • Dermatology and endocrinology, focusing on skin physiology and hormone action.

Background:

  • Oestrogens play a crucial role in various skin functions.
  • They influence epidermal keratinocytes, dermal fibroblasts, melanocytes, hair follicles, sebaceous glands, and apocrine glands.
  • Oestrogens are implicated in skin aging, pigmentation, hair growth, sebum production, and skin cancer.

Purpose of the Study:

  • To highlight the multifaceted effects of oestrogens on diverse skin components.
  • To review recent advancements in understanding oestrogen receptor expression and signaling pathways in the skin.

Main Methods:

  • Review of existing literature on oestrogen's effects on skin cells and appendages.
  • Analysis of studies detailing oestrogen receptor (ERalpha and ERbeta) expression.
  • Examination of research on cell surface receptor-mediated signaling pathways.

Main Results:

  • Oestrogens modulate key skin cell types and appendages.
  • Actions are mediated via intracellular receptors (ERalpha, ERbeta) and cell surface receptors.
  • Specific signaling pathways activated by oestrogens in skin cells have been identified.

Conclusions:

  • Oestrogens exert significant regulatory effects on skin structure and function.
  • Understanding oestrogen receptor subtypes and signaling pathways is key to comprehending oestrogen's role in skin health and disease.
  • Further research into these mechanisms can inform therapeutic strategies for skin conditions.

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