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Updated: Aug 17, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Molecular aetiology and pathogenesis of basal cell carcinoma
C M L J Tilli1, M A M Van Steensel, G A M Krekels
1Research Institute of Growth & Development, Department of Dermatology, University of Masstricht, The Netherlands.
Abstract:
Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The significant progress that has been made warrants a comprehensive review of the molecular and cellular pathology of BCC. The items addressed include environmental and genetic risk factors, the biology of the putative precursor cell(s), and the contribution of aberrations in processes such as apoptosis, cell proliferation, differentiation and signalling to carcinogenesis. Furthermore, established and novel treatment modalities are discussed with particular attention to future biological approaches.
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