Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Challenges to understanding and measuring carotenoid bioavailability.

Richard Martin Faulks1, Susan Southon

  • 1Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK.

Biochimica Et Biophysica Acta
|June 14, 2005
PubMed
Summary

Understanding carotenoid bioavailability requires considering food structure, digestion, and individual differences. Key challenges include carotenoid release (bioaccessibility) and absorption, impacting study interpretations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion.

Food microbiology·2011
Same author

Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract.

Food microbiology·2010
Same author

Kinetics of gastro-intestinal transit and carotenoid absorption and disposal in ileostomy volunteers fed spinach meals.

European journal of nutrition·2004
Same author

DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo.

The British journal of nutrition·2004
Same author

Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes.

The British journal of nutrition·2004
Same author

Plasma and buccal mucosal cell response to short-term supplementation with all trans-beta-carotene and lycopene in human volunteers.

International journal of molecular medicine·2003

Area of Science:

  • Nutritional Science
  • Food Chemistry
  • Human Physiology

Background:

  • Carotenoid bioavailability is complex, often misinterpreted due to poor understanding of food structure and digestion.
  • Inter-individual variations in response further complicate accurate measurement and interpretation of carotenoid studies.

Purpose of the Study:

  • To discuss challenges in understanding and measuring carotenoid bioavailability.
  • To highlight factors affecting carotenoid release (bioaccessibility) and absorption from food and supplements.
  • To propose improved methods for assessing carotenoid absorption, accounting for individual metabolic differences.

Main Methods:

  • Review of factors influencing carotenoid bioaccessibility, including food matrix properties and processing.
  • Analysis of carotenoid absorption determinants, such as fat intake and supplement formulation.

Related Experiment Videos

  • Discussion of plasma response interpretation and inter-individual variability in carotenoid metabolism.

    • Main Results:

    • Carotenoid bioaccessibility depends on food matrix structure and digestion efficiency.
    • Carotenoid release from plant cells occurs during food preparation, not digestion.
    • Absorption is influenced by fat consumption with supplements and carotenoid dispersion in food colorants.

    Conclusions:

    • Accurate carotenoid bioavailability assessment requires addressing bioaccessibility and absorption challenges.
    • Measuring chylomicron carotenoid excursion and modeling turnover rate offers a better approach to absorption studies.
    • Improved methodologies can account for inter-individual differences in lipoprotein metabolism for more reliable conclusions.