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Thyroid function after assisted reproductive technology in women free of thyroid disease
Kris Poppe1, Daniel Glinoer, Herman Tournaye
1Department of Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium. hemopek@az.vub.ac.be
Objective:
To evaluate thyroid function in women undergoing a first assisted reproductive technology (ART) procedure and to compare women with ongoing pregnancy or miscarriage.
Design:
Prospective cohort study.
Setting:
Tertiary referral center.
Patient(S):
Seventy-seven women free of thyroid disease.
Intervention(S):
Serum TSH and FT4 were determined before and 2, 4, and 6 weeks after ET. All women received the same ART protocol.
Main Outcome Measure(S):
Thyroid function.
Result(S):
Forty-five women had ongoing pregnancies, and 32 suffered a miscarriage after 6.7 weeks (range 5-11). Mean age and number of ET were similar in both groups. Compared with baseline values, TSH and FT4 increased significantly 2 weeks after ET (ongoing pregnancies group: TSH 2.5 +/- 1.3 vs. 1.6 +/- 0.8 mU/L and FT4 13.8 +/- 1.4 vs. 12.4 +/- 1.8 ng/L; miscarriage group: TSH 2.1 +/- 1.0 vs. 1.5 +/- 0.7 mU/L and FT4 14.2 +/- 2.0 vs. 12.4 +/- 1.9 ng/L). Pregnancy outcome did not affect thyroid function and its evolution over time.
Conclusion(S):
In women free of thyroid diseases, thyroid function changed significantly after ART, but these changes were not different between women with ongoing pregnancy and miscarriage.
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