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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
Published on: March 24, 2017
Cloning and characterisation of the primary structure of the sheep lymphocyte function-associated antigen-1 alpha
1Department of Pathology, Faculty of Veterinary Medicine, University of Liège, FMV Sart Tilman B43, B-4000 Liège, Belgium.
Abstract:
The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. The ovine cDNA encoding CD11a, the predominant alpha subunit of the beta2-integrin family, was sequenced and compared with the human, bovine and murine sequences. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues. Along with the ovine CD18-encoding cDNA, which is available for a few months, the sequence data provided here will allow the Ovis aries beta2-integrin CD11a/CD18 (LFA-1, alpha(L)beta2) expression in vitro as a tool to examine the specificities of inflammation in the ovine species.
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