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Related Experiment Videos

IgM accelerates affinity maturation.

R B Corley1, E M Morehouse, A R Ferguson

  • 1Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. rbcorley@bu.edu

Scandinavian Journal of Immunology
|June 15, 2005
PubMed
Summary
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Secreted Immunoglobulin M (IgM) accelerates antibody affinity maturation for T-dependent antigens. This suggests an optimal antigen level is needed for high-affinity antibody generation and highlights IgM's role in T cell induction.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Secreted Immunoglobulin M (IgM) acts as a potent adjuvant, concentrating antigens in lymphoid organs to initiate antibody responses.
  • IgM is crucial for germinal center formation and resolving infections.

Purpose of the Study:

  • To investigate the influence of specific IgM on the quantity and quality of antibody produced against T-dependent and T-independent antigens.
  • To determine IgM's role in affinity maturation and T cell induction.

Main Methods:

  • Mice were challenged with T-dependent and T-independent antigens, with and without specific IgM.
  • Low and high concentrations of IgM-containing immune complexes (IgM-IC) were administered.
  • Antigen deposition, antibody titre, duration, and affinity maturation were analyzed.

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Main Results:

  • Specific IgM did not significantly affect antibody titre or duration for either antigen type.
  • Low doses of IgM-IC with T-dependent antigens accelerated affinity maturation compared to antigen alone.
  • Higher IgM-IC concentrations increased follicular antigen deposition but did not enhance affinity maturation.
  • IgM complexed with T-independent antigens did not affect antibody responses despite increased antigen deposition.

Conclusions:

  • IgM accelerates affinity maturation in T-dependent immune responses, indicating an antigen optimum for high-affinity antibody generation.
  • IgM plays a significant role in inducing CD4 T cells, promoting germinal center formation and function.