Related Experiment Video
Updated: Aug 17, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
Platelet apheresis affects prothrombin time and plasminogen levels in healthy donors
Cengiz Beyan1, Kürşat Kaptan, Serap Savaşçi
1Department of Hematology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey. cengizbeyan@hotmail.com
Abstract:
There are few studies evaluating whether platelet apheresis has an effect on hemostasis parameters or not. The aim of this study was to define the effects of platelet apheresis on hemostasis screening tests and plasminogen levels. The study was performed on 40 healthy donors. We compared the values obtained before and after apheresis and observed that the prothombin time (PT) elongated, plasminogen levels decreased and the activated partial thromboplastin and thrombin times were not changed significantly. The differences were not high enough to cause any hemostasis problem. It can be hypothesized that platelet apheresis affects PT and plasminogen levels in healthy donors.
More Related Videos
14:38Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
08:01The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
Related Concept Videos
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Clot Retraction and Fibrinolysis
Venous Thrombosis III: Interprofessional Care
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.