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Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study

Toshiharu Ninomiya1, Yutaka Kiyohara, Michiaki Kubo

  • 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nino@intmed2.med.kyushu-u.ac.jp

Kidney International
|June 16, 2005
PubMed

Insights

Chronic kidney disease is an independent risk factor for cardiovascular disease in the general Japanese population, particularly for coronary heart disease in men and ischemic stroke in women.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a known cardiovascular disease (CVD) risk factor in high-risk groups.
  • The association between CKD and CVD in community-based populations remains unclear.

Purpose of the Study:

  • To investigate the relationship between CKD and the incidence of CVD.
  • To clarify the independent role of CKD as a CVD risk factor in a general population.

Main Methods:

  • A 12-year prospective study of 2634 community-dwelling individuals aged 40+ without pre-existing CVD.
  • Examined the incidence of coronary heart disease, ischemic stroke, and hemorrhagic stroke in relation to CKD status.

Main Results:

  • CKD was associated with a higher incidence of coronary heart disease in men and ischemic stroke in women.
  • Multivariate analysis confirmed CKD as an independent risk factor for coronary heart disease in men (HR 2.26) and ischemic stroke in women (HR 1.91).
  • No association was found between CKD and hemorrhagic stroke.

Conclusions:

  • CKD is an independent risk factor for cardiovascular disease in the general Japanese population.
  • The study highlights sex-specific associations of CKD with different CVD subtypes.
Abstract

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