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Updated: Oct 22, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
Microvascular inflammation in kidney transplants: finally an effective treatment?
Mark Haas1, Jean Hou1, Agnes B Fogo2
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Abstract:
Microvascular inflammation-glomerulitis and peritubular capillaritis-is the hallmark histologic lesion of antibody-mediated allograft rejection and may also occur in the absence of donor-specific antibodies. In either case, microvascular inflammation leads to graft loss, and it has proven difficult to treat. As demonstrated in a study in this issue of Kidney International, targeting CD38, a glycoprotein expressed on both plasma cells and natural killer cells, shows great promise in treating microvascular inflammation in kidney transplants.
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