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Anti-tumor necrosis factor alpha-associated multiple sclerosis.
David S Titelbaum1, Alexandra Degenhardt, R Philip Kinkel
1Department of Radiology, Shields Health Care, Brockton, MA 02301, USA.
AJNR. American Journal of Neuroradiology
|June 16, 2005
Summary
Multiple sclerosis (MS) can occur during anti-tumor necrosis factor therapy for rheumatoid arthritis. Radiologists should be aware of this association to potentially identify MS early.
Area of Science:
- Neurology
- Immunology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Anti-tumor necrosis factor (anti-TNF) agents are used to treat RA.
- A potential association between anti-TNF therapy and new-onset multiple sclerosis has been noted.
Observation:
- A case is presented where multiple sclerosis manifested in a patient undergoing anti-TNF treatment for rheumatoid arthritis.
- This specific clinical scenario highlights a rare but significant presentation.
Findings:
- The occurrence of multiple sclerosis during anti-TNF therapy for RA is a recognized, albeit infrequently reported, phenomenon in nonradiological literature.
- This association suggests a complex interplay between autoimmune disease treatment and neurological conditions.
Implications:
- Radiologists play a crucial role in the early detection of neurological disorders.
- Awareness of this association can aid radiologists in identifying potential cases of multiple sclerosis in patients on anti-TNF therapy.
- Prompt diagnosis can lead to timely management and improved patient outcomes.