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Related Experiment Videos

MR diffusion tensor imaging and fiber tracking in spinal cord compression.

David Facon1, Augustin Ozanne, Pierre Fillard

  • 1Department of Neuroradiology, C.H.U. de Bicêtre, Paris XI University, Le Kremlin-Bicêtre, France.

AJNR. American Journal of Neuroradiology
|June 16, 2005
PubMed
Summary

Fractional anisotropy (FA) demonstrates superior sensitivity and specificity for detecting spinal cord abnormalities compared to other diffusion tensor imaging metrics. Fiber tracking aids in precise localization of spinal cord compression.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Medical Physics

Background:

  • Spinal cord damage leads to significant functional disability.
  • Diffusion tensor imaging (DTI) assesses spinal cord structural integrity.
  • DTI metrics like apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are key.

Purpose of the Study:

  • Evaluate diagnostic accuracy of ADC, FA, and fiber tracking.
  • Assess these metrics in acute and slowly progressive spinal cord compressions.

Main Methods:

  • Prospective study of 15 patients with spinal cord compression and 11 healthy volunteers.
  • Utilized 1.5-T MRI with T2-weighted FSE and DTI sequences.
  • Computed ADC and FA maps; employed fiber tracking in select cases.

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  • Statistical analysis included sensitivity and specificity calculations.

    • Main Results:

    • FA showed significantly higher sensitivity (73.3%) and specificity (100%) for spinal cord abnormalities than T2 FSE (46.7%, 100%) and ADC (13.4%, 80%).
    • Patients with compression exhibited decreased FA values compared to healthy controls (P = .012).
    • Fiber tracking precisely localized compression in three patients.

    Conclusions:

    • Fractional anisotropy (FA) is highly sensitive and specific for detecting spinal cord abnormalities.
    • Spinal cord fiber tracking is valuable for precise measurement in compressed areas.