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Updated: Aug 17, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Selective cytolysis of tumor cells by mumps virus S79

Yin-Fang Yan1, Xiao Chen, Ying Zhu

  • 1Institute of Medical Virology, Wuhan University, Wuhan, People's Republic of China. yanyinfang11@yahoo.com.ch

Intervirology
|June 16, 2005
PubMed

Insights

Live mumps virus (MuV) S79 effectively regressed fibrosarcoma tumors in mice. Cancer cells showed varied sensitivity to MuV infection, with ACHN cells being most susceptible.

Area of Science:

  • Oncology
  • Virology
  • Biotechnology

Background:

  • Mumps virus (MuV) S79, a live attenuated vaccine strain, has potential therapeutic applications.
  • Understanding differential cancer cell sensitivity to viral infection is crucial for developing oncolytic virotherapies.

Purpose of the Study:

  • To evaluate the sensitivity of various human cancer and normal cell strains to MuV S79 infection.
  • To assess the efficacy of intratumoral MuV S79 treatment in a mouse model of HT1080 fibrosarcoma.

Main Methods:

  • In vitro: Assessed MuV S79 infection sensitivity across HeLa, HT1080, SPC-A1, ACHN, MRC-5, and Wish cell lines.
  • In vivo: Treated nude mice bearing HT1080 fibrosarcoma xenografts with live MuV S79, UV-inactivated MuV S79, or PBS.

Main Results:

  • Differential sensitivity to MuV infection observed: ACHN > HeLa > HT1080 > SPC-A1 > Wish > MRC-5.
  • Intratumoral injection of live MuV S79 led to complete regression in 7 of 9 mice by day 15.
  • UV-inactivated MuV S79 showed delayed tumor growth compared to PBS controls, while PBS resulted in rapid tumor progression.

Conclusions:

  • Live MuV S79 demonstrates significant oncolytic potential against HT1080 fibrosarcoma in vivo.
  • Cancer cell susceptibility to MuV infection varies, suggesting potential for targeted oncolytic virotherapy.
  • Further research into MuV S79 as an oncolytic agent is warranted.

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