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Updated: Aug 17, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
A concise synthesis of (+)-SCH 351448
Omid Soltani1, Jef K De Brabander
1Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
Abstract:
[structure: see text] We describe a highly convergent synthetic approach to the natural product (+)-SCH 351448 (1)-a hexane-soluble heptacoordinate monosodium salt of a C(2)-symmetrical macrocyclic dilactone. Our approach implements a photochemical acylation as the key step to combine two nearly identical but orthogonal C1-C29 fragments, followed by a base-induced intramolecular acylation and deprotection to yield the natural product.
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