Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array

Thomas S Price1, Regina Regan, Richard Mott

  • 1The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Churchill Hospital Headington, Oxford OX3 7BN, UK.

Nucleic Acids Research
|June 18, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.

Nature communications·2026
Same author

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.

Nature communications·2026
Same author

Single-Cell Spatial Transcriptomics Reveals Sex-Specific Differences Driving Carotid Atherosclerotic Plaque Instability.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease.

JACC. Basic to translational science·2026
Same author

Co-occurring rare germline DNA repair gene variants in BRCA1/BRCA2 implicated hereditary breast cancer families.

NPJ breast cancer·2026
Same author

<i>De novo</i> whole-genome assembly of the <i>Wolbachia</i> sp. endosymbiont from <i>Anastrepha fraterculus</i> using long- and short-read metagenomic data.

Microbiology resource announcements·2026

A new SW-ARRAY analysis method improves copy-number change detection in array comparative genome hybridization (array CGH) data. This robust approach enhances accuracy for genomic deletions and duplications, addressing clinical diagnostic concerns.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Array comparative genome hybridization (array CGH) is a high-resolution technique for detecting genomic copy-number variations.
  • Previous array CGH studies have reported false positives and negatives, limiting clinical diagnostic applications.

Purpose of the Study:

  • To develop a sensitive and robust analytical method for array CGH data.
  • To improve the detection of copy-number changes, specifically deletions and duplications, in the human genome.

Main Methods:

  • Adaptation of the Smith-Waterman dynamic-programming algorithm to create the SW-ARRAY analytic approach.
  • Application of SW-ARRAY to array CGH data from human chromosome 16p tiling path arrays in a blind hybridization series.

Related Experiment Videos

Main Results:

  • SW-ARRAY identified all monosomies within the 267-1567 kb range with high statistical significance.
  • The method accurately delineated deletion boundaries from 267-1052 kb.
  • The approach incorporates nonparametric segmentation and significance testing.

Conclusions:

  • The SW-ARRAY method offers a sensitive and robust solution for analyzing array CGH data.
  • This approach enhances the reliability of detecting copy-number variations, supporting clinical diagnostics.
  • SW-ARRAY is scalable and suitable for high-resolution whole-genome array CGH studies using various probe types.