Related Experiment Video
Updated: Aug 17, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic
Jennifer E Mitchell1, Anne P Campbell, Norman E New
1Department of Cellular Pathology, Hull Royal Infirmary, Hull, United Kingdom.
Abstract:
TRPV1 is a modulator of noxious stimuli known to be important in the cough reflex. We have compared the expression of TRPV1 in normal human airways and those from patients with chronic cough and found that there is up regulation in airways smooth muscle in disease. This increased expression appears to be intracellular and we have therefore examined the role of intracellular rat and human TRPV1 activity was found using intracellular calcium signalling with human intracellular TRPV1 being located in a thapsigargin insensitive compartment. Increase in TRPV1 activity may have a role in the airway hypersensitivity seen in chronic cough.
Related Concept Videos
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Asthma III: Clinical Manifestations
Antiasthma Drugs: Muscarinic Receptor Antagonists
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Asthma I: Introduction

