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Rifampin-resistant meningococcal disease

Jean Rainbow1, Elizabeth Cebelinski, Joanne Bartkus

  • 1Minnesota Department of Health, Minneapolis, Minnesota 55414, USA. jean.rainbow@health.state.mn.us

Emerging Infectious Diseases
|June 21, 2005
PubMed

Insights

Rifampin-resistant meningococcal disease is rare, even after prophylaxis. Point mutations in the rpoB gene were identified in the rare cases of rifampin-resistant Neisseria meningitidis.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Neisseria meningitidis causes meningococcal disease.
  • Rifampin is a key antibiotic for chemoprophylaxis to prevent secondary cases.
  • Antibiotic resistance is a growing public health concern.

Purpose of the Study:

  • To report a rare case of rifampin-resistant meningococcal disease.
  • To investigate the prevalence of rifampin resistance in Neisseria meningitidis.

Main Methods:

  • Case study of a child receiving rifampin chemoprophylaxis.
  • Statewide surveillance of Neisseria meningitidis isolates over 11 years.
  • Antimicrobial susceptibility testing and molecular analysis (rpoB gene sequencing).

Main Results:

  • One case of rifampin-resistant meningococcal disease was identified in a child who completed chemoprophylaxis.
  • Only one additional case of rifampin resistance was found among 331 isolates over 11 years.
  • Rifampin-resistant isolates harbored point mutations in the rpoB gene.

Conclusions:

  • Rifampin-resistant meningococcal disease is exceptionally rare.
  • Mutations in the rpoB gene are associated with rifampin resistance in Neisseria meningitidis.
  • Continued surveillance is important for monitoring antibiotic resistance patterns.

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